3D structure of enzyme helps defend against bacteria An important weapon in the body&39.
The 3D framework uncovered by Korennykh and his team includes two nearly identical subunits called protomers. The researchers discovered that one protomer finds and attaches to the RNA, while the various other protomer snips it. The original protomer latches onto one of the four ‘letters’ that make up the RNA code, in particular, the ‘U,’ which means an element of RNA called uridine. The various other protomer ‘counts’ RNA letters starting from the U, skips exactly one letter, then cuts the RNA.Hui-Ming Luo, M.D., Yong Zhang, M.D., Ph.D., Xin-Qi Wang, M.D., Wen-Zhou Yu, M.D., Ph.D., M.P.H., Ning Wen, M.Sc., Dong-Mei Yan, M.Sc., Hua-Qing Wang, M.D., Ph.D., Fuerhati Wushouer, M.D., Hai-Bo Wang, M.D., Ph.D., Ai-Qiang Xu, M.D., Jing-Shan Zheng, M.D., De-Xin Li, M.D., Hui Cui, B.Sc., Jian-Ping Wang, M.Sc., Shuang-Li Zhu, B.Sc., Zi-Jian Feng, M.D., Fu-Qiang Cui, M.D., Ph.D., M.P.H., Jing Ning, B.Sc., Li-Xin Hao, M.D., Ph.D., Chun-Xiang Lover, M.Sc., Gui-Jun Ning, M.Sc., Hong-Jie Yu, M.D., Shi-Wen Wang, M.D., Ph.D., Da-Wei Liu, M.D., Dong-Yan Wang, B.Sc., Jian-Ping Fu, M.D., Ai-li Gou, B.Sc., Guo-Min Zhang, Ph.D., Guo-Hong Huang, B.Sc., Yuan-Sheng Chen, M.D., Ph.D., Sha-Sha Mi, M.D., Yan-Min Liu, M.D., Da-Peng Yin, Ph.D., Hui Zhu, B.Sc., Xin-Chun Enthusiast, B.Sc., Xin-Lan Li, B.Sc., Yi-Xin Ji, M.Sc., Ke-Li Li, M.D., Hai-Shu Tang, M.Sc., Wen-Bo Xu, M.D., Yu Wang, M.D., Ph.D., M.P.H, and Wei-Zhong Yang, M.D.: Identification and Control of a Poliomyelitis Outbreak in Xinjiang, China The World Health Assembly established the Global Polio Eradication Initiative in 1988.1,2 The Globe Health Corporation Western Pacific region, including China, was qualified as a poliomyelitis-free region in 2000.3 However, the transmission of wild-type poliovirus hasn’t yet been stopped in Afghanistan, Pakistan, or Nigeria.