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The partnership between clinical status and ANCA specificity can be shown in Figure 2AFigure 2Interactions between Clinical Subtype and ANCA Specificity in ANCA-Associated Vasculitis and Associations of the MHC Locus with Proteinase 3 ANCA and Myeloperoxidase ANCA. . Direct comparisons between the subgroup of patients with proteinase 3 ANCA and the subgroup with myeloperoxidase ANCA showed significant differences at the MHC, SERPINA1, and PRTN3 loci, all consisting of there being a genetic association with proteinase 3 ANCA but not myeloperoxidase ANCA . In all cases, both the odds ratios and P values show a stronger association with proteinase 3 ANCA than with granulomatosis with polyangiitis. This was clear for PRTN3 particularly, which was conclusively associated with proteinase 3 ANCA status whereas it had not been with total ANCA-connected vasculitis or granulomatosis with polyangiitis .