Patients in whom progressive disease developed during induction or consolidation therapy were treated according to local standards and remained in the trial for later on outcome evaluations. Maintenance therapy was initiated within the first three months after completion of consolidation therapy. Maintenance therapy with lenalidomide was administered until disease progression or the development of unacceptable undesireable effects. Information on dose reductions, drug discontinuations, and treatment schedules are given in Desk S1 in the Supplementary Appendix, available at NEJM.org. Information on the anticoagulation regimen used have already been published previously. 22 End Factors and Assessments The principal study end point was progression-free survival. Secondary end points included general survival, the overall response rate, the right time to a reply, and safety.It can deplete the body of alkaline minerals such as for example sodium, potassium, magnesium, and calcium, making people prone to chronic and degenerative disease. What is usually Alkaline and just why is it Important? Alkaline occurs in our bodies naturally, and its main function is to neutralize excess acids and remove them from the physical body. It is important to keep sufficient alkaline levels, because when our alkaline levels are low, our anatomies deplete essential nutrition from organs and other body parts in order to neutralize the surplus acid.