Mark FitzGerald.

Hector G. Ortega, M .D., Sc.D., Tag C. Liu, M.D., Ian D. Pavord, D.M., Man G. Brusselle, M.D., J. Mark FitzGerald, M.D., Alfredo Chetta, M.D., Marc Humbert, M.D., Ph.D., Lynn E. Katz, Pharm.D., Oliver N. Keene, M.Sc., Steven W. Yancey, M.Sc., and Pascal Chanez, M.D., Ph.D. For the MENSA Investigators: Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma Severe asthma affects less than 10 percent of individuals with asthma and is usually associated with substantial morbidity and mortality and a big fraction of medical care costs among sufferers with asthma.1-3 Despite available care, recurrent asthma exacerbations certainly are a major concern in a subgroup of individuals with eosinophilic airway irritation.4-6 Mepolizumab, a humanized monoclonal antibody against interleukin-5, inhibits eosinophilic inflammation7 selectively, 8 and reduces the amount of eosinophils in both sputum and blood, resulting in a decrease in exacerbations and in the necessity for treatment with systemic glucocorticoids.7-12 In the Dosage Ranging Efficacy and Basic safety with Mepolizumab research13 of intravenous mepolizumab, investigators defined key phenotypic features of the prospective population that were connected with a reply to treatment with mepolizumab.

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