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Patients with transient lacunar ischemic attacks were included only when there was proof the attacks on diffusion-weighted MRI. MRI scans were assessed by the investigators at each study site and submitted for interpretation by a neuroradiologist located at the SPS3 Coordinating Middle. Patients with MRI evidence of a remote or recent cortical infarct, a big subcortical infarct , or a brief history of intracerebral hemorrhage were excluded .17 Additional exclusion criteria had been disabling stroke and earlier intracranial hemorrhage or cortical ischemic stroke. Outcomes The principal hypothesis was that clopidogrel added to aspirin would be superior to aspirin alone in reducing the principal outcome of stroke recurrence .