Treatment and Randomization This multinational trial was conducted in 26 countries; 189 centers enrolled individuals. Enrollment was preceded by a safety run-in phase.24 Between April 2010 and July 2012, individuals were enrolled and randomly assigned to one of the following treatment groupings on a 1:2:2 basis: chlorambucil alone, chlorambucil plus obinutuzumab, or chlorambucil plus rituximab. After 118 patients have been designated to the chlorambucil-alone group, this combined group was closed on the basis of predefined criteria, and randomization to the two antibody groupings was performed on a 1:1 basis. Randomization was stratified relating to geographic region and Binet stage.The WHO Medical Safety Checklist was made as a device to make sure adherence to safeness standards of treatment. With this award AcademyHealth recognizes analysis that obviously translated into policy and, ultimately, made our health care program better, said AcademyHealth President W. David Helms, Ph.D. The WHO Surgical Protection Checklist exemplifies how health services study can inform the decision making process and ultimately influence the lives of Us citizens in a positive and beneficial manner. In 2006 the World Health Business asked Dr. Atul Gawande to develop an approach to reduce surgical damage globally. Over another two years, Dr. Gawande led a team of international experts from surgery, anesthesiology, and nursing in defining a core group of safety standards which can be put on high and low income countries as well.